Cinnabarinic acid

Cat. No. 4119

Cinnabarinic acid C14H8N2O6 [606-59-7]

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Chemical Name: 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid

Biological Activity

mGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Fazio (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors. Mol.Pharmacol. Feb 6 Epub ahead of print. PMID: 22311707.

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Keywords: Cinnabarinic acid, supplier, metabotropic, glutamate, mglu4, agonists, selective, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Agonist products

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