Cat. No. 4119
Chemical Name: 2-Amino-3-oxo-3H-phenoxazine-1,9-di
Biological ActivitymGlu4 receptor agonist. Activates mGlu4 receptors in transiently transfected HEK293 cells; selective over all other mGlu subtypes (mGlu1, mGlu2 and mGlu5-8). Decreases cAMP levels in native cultured cerebellar granule cells. Also counteracts excitotoxic neuronal cell death induced by NMDA in mixed cultures of cortical cells; displays neuroprotective activity.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fazio (2012) Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type-4 metabotropic glutamate receptors. Mol.Pharmacol. Feb 6 Epub ahead of print. PMID: 22311707.
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Keywords: Cinnabarinic acid, supplier, metabotropic, glutamate, mglu4, agonists, selective, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Agonist products