SB 772077B dihydrochloride
Cat. No. 4118
Chemical Name: (3S)-1-[[2-(4-Amino-1,2,5-oxadiazol
Biological ActivityPotent Rho-kinase (ROCK) inhibitor (IC50 value of approximately 5.6 nM at recombinant human ROCK1 and 2). Decreases pulmonary and systemic arterial blood pressures and increases cardiac output. Exhibits vasodilator activity that is more potent than Y-27632 (Cat.No 1254) or Fasudil (Cat.No. 0541).
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Dhaliwal et al (2009) Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor. J.Pharm.Exp.Ther. 330 334.
Doe et al (2007) Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J.Pharm.Exp.Ther. 320 89.
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Keywords: SB 772077B dihydrochloride, supplier, SB772077B, 2HCl, Rho, Kinase, inhibitors, inhibits, ROCK, anti-inflammatory, vasodilators, antihypertensive, Tocris Bioscience, Rho-Kinases Inhibitor products
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