Cat. No. 4117
Chemical Name: N-Benzyl-N-(3-isobutoxy-2-pyrrolidi
Biological ActivityCalcium channel blocker. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; opens mitochondrial KATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Sato et al (2006) Bepridil, an antiarrythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J.Pharmacol.Exp.Ther. 316 182. PMID: 16174795.
Wantanabe and Kimura (2001) Blocking effect of bepridil on Na+/ Ca2+ exchange current in gunea pig cardiac ventricular myocytes. Jpn.J.Pharmacol. 85 370. PMID: 11388640.
Gill et al (1992) Pharmacology of bepridil. Am.J.Cardiol. 69 11D. PMID: 1372785.
Yatani et al (1986) Bepridil block of cardiac calcium and sodium channels. J.Pharmacol.Exp.Ther. 237 9. PMID: 2420970.
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Citations are publications that use Tocris products. Selected citations for Bepridil hydrochloride include:
Ciapa and Philippe (2013) Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS One 8 e66113. PMID: 23785474.
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Keywords: Bepridil hydrochloride, supplier, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, NCX, sodium-calcium, exchangers, KATP, antiarrhythmics, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products