Bepridil hydrochloride

Cat. No. 4117

Bepridil hydrochloride C24H34N2O.HCl [68099-86-5]

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Chemical Name: N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride

Biological Activity

Calcium channel blocker. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; opens mitochondrial KATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.

Technical Data

M.Wt:
403
Formula:
C24H34N2O.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
68099-86-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sato et al (2006) Bepridil, an antiarrythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J.Pharmacol.Exp.Ther. 316 182. PMID: 16174795.

Wantanabe and Kimura (2001) Blocking effect of bepridil on Na+/ Ca2+ exchange current in gunea pig cardiac ventricular myocytes. Jpn.J.Pharmacol. 85 370. PMID: 11388640.

Gill et al (1992) Pharmacology of bepridil. Am.J.Cardiol. 69 11D. PMID: 1372785.

Yatani et al (1986) Bepridil block of cardiac calcium and sodium channels. J.Pharmacol.Exp.Ther. 237 9. PMID: 2420970.

If you know of a relevant reference for Bepridil hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Bepridil hydrochloride include:

Ciapa and Philippe (2013) Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS One 8 e66113. PMID: 23785474.

Do you know of a great paper that uses Bepridil hydrochloride from Tocris? If so please let us know.

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Keywords: Bepridil hydrochloride, supplier, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, NCX, sodium-calcium, exchangers, KATP, antiarrhythmics, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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