GSK 9027

Cat. No. 4116

GSK 9027 C27H19F4N3O2S [1229096-88-1]

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Chemical Name: N-[4-[1-(4-Fluorophenyl)-1H-indazol-5-yl-3-(trifluoromethyl)phenyl]benzenesulfonamide

Biological Activity

Glucocorticoid receptor agonist (pIC50 = 8). Inhibits production of the proinflammatory mediator IL-6 in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

M.Wt:
525.52
Formula:
C27H19F4N3O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
1229096-88-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yates et al (2010) Structure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists. J.Med.Chem. 53 4531. PMID: 20469868.

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Keywords: GSK 9027, supplier, gsk, GSK9027, glucocorticoid, receptors, agonists, Tocris Bioscience, Glucocorticoid Receptor Agonist products

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