Cat. No. 4112
Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicot
Biological ActivityNonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Deng et al (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci.Rep. 2 373. PMID: 22523636.
Hu et al (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459 579. PMID: 19888597.
Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437. PMID: 9427063.
Ottolia and Toro (1994) Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J. 67 2272. PMID: 7535111.
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Citations are publications that use Tocris products. Selected citations for Niflumic acid include:
Cao et al (2014) SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability. J Neuroinflammation 289 23189. PMID: 24962569.
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Keywords: Niflumic acid, supplier, cyclooxygenase, 2, cox-2, inhibitors, inhibits, Tocris Bioscience, Cyclooxygenase Inhibitor products