Niflumic acid

Cat. No. 4112

Niflumic acid C13H9F3N2O2 [4394-00-7]

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Chemical Name: 2-[3-(Trifluoromethyl)anilino]nicotinic acid

Biological Activity

Nonsteroidal anti-inflammatory drug (NSAID); selectively inhibits COX-2. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.

Technical Data

M.Wt:
282.22
Formula:
C13H9F3N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store at RT
CAS No:
4394-00-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Deng et al (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci.Rep. 2 373. PMID: 22523636.

Hu et al (2010) Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch. 459 579. PMID: 19888597.

Famaey (1997) In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflamm.Res. 46 437. PMID: 9427063.

Ottolia and Toro (1994) Potentiation of large conductance KCa channels by niflumic, flufenamic and mefenamic acids. Biophys.J. 67 2272. PMID: 7535111.

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Keywords: Niflumic acid, supplier, cyclooxygenase, 2, cox-2, inhibitors, inhibits, Tocris Bioscience, Cyclooxygenase Inhibitor products

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