Cat. No. 4111
Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylene
Biological ActivityNicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dasgupta et al (2010) Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci. 103 6332.
Karavaev et al (2008) The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 38 297. PMID: 18264777.
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Keywords: Hexamethonium bromide, supplier, Hexamethonium, Br, nicotinic, receptor, blocker, ganglion, nAChR, antagonist, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products