Cat. No. 4111
Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylene
Biological ActivityNicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Dasgupta et al (2010) Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci. 103 6332.
Karavaev et al (2008) The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 38 297. PMID: 18264777.
If you know of a relevant reference for Hexamethonium bromide please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Hexamethonium bromide from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Hexamethonium bromide, supplier, Hexamethonium, Br, nicotinic, receptor, blocker, ganglion, nAChR, antagonist, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products
Find multiple products by catalog number
New Products in this Area
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.