Hexamethonium bromide

Cat. No. 4111

Hexamethonium bromide C12H30Br2N2 [55-97-0]

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Chemical Name: N,N,N,N',N',N'-Hexamethylhexamethylenediammonium dibromide

Biological Activity

Nicotinic receptor (nAChR) blocker at autonomic ganglia; prevents nicotine-mediated inhibition of apoptosis. Induces changes in neuronal activity similar to the influences of glutamate in vitro. Inhibits nicotine-mediated induction of XIAP and survivin.

Technical Data

Soluble to 100 mM in water and to 50 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Dasgupta et al (2010) Nicotine inhibits apoptosiis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc.Natl.Acad.Sci. 103 6332.

Karavaev et al (2008) The nicotinic receptor blocker hexamethonium alters neuronal responses to glutamate in the medial septal area of the brain of the ground squirrel in vitro. Neurosci.Behav.Physiol. 38 297. PMID: 18264777.

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Keywords: Hexamethonium bromide, supplier, Hexamethonium, Br, nicotinic, receptor, blocker, ganglion, nAChR, antagonist, Tocris Bioscience, Nicotinic Receptor (Non-selective) Antagonist products

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