Cat. No. 4108

Quinidine C20H24N2O2 [56-54-2]

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Chemical Name: (S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride

Biological Activity

Class IA antiarrythmic; reduces both Na+ and K+ channel currents, including INa, IKr and IKs. Prolongs QT and induces torsade de pointes (TdP).

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in ethanol
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wu et al (2008) Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine. Heart Rhythm. 5 1726. PMID: 19084812.

Borggrefe et al (2005) Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 38 75. PMID: 16226079.

Caballero et al (2003) Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 138 1475. PMID: 12721103.

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Keywords: Quinidine, supplier, sodium, Na+, potassium, K+, channel, blockers, IKr, IKs, IK1, IK-ATP, Ito, INa, antiarrhythmic, class, 1A, torsade, de, pointes, prolongs, qt, interval, Tocris Bioscience, Other Channel Modulator products

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