Cat. No. 4107
Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid
Biological ActivityInhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504. PMID: 20190417.
Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761. PMID: 18596212.
Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337. PMID: 17374608.
Cunningham et al (1981) Clinical pharmacokinetics of probenecid. Clin.Pharmacokinet. 6 135. PMID: 7011657.
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Citations are publications that use Tocris products. Selected citations for Probenecid include:
Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci 21 74. PMID: 25096780.
Asgari et al (2013) C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. J Biol Chem 122 3473. PMID: 23878142.
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Keywords: Probenecid, supplier, ATP-binding, cassette, ABC, multidrug, resistance-associated, proteins, MRP, inhibitors, inhibits, Tocris Bioscience, Multidrug Transporter Inhibitor products