Cat. No. 4107
Chemical Name: 4-(Dipropylsulfamoyl)benzoic acid
Biological ActivityInhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504. PMID: 20190417.
Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761. PMID: 18596212.
Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337. PMID: 17374608.
Cunningham et al (1981) Clinical pharmacokinetics of probenecid. Clin.Pharmacokinet. 6 135. PMID: 7011657.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Probenecid include:
Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci 21 74. PMID: 25096780.
Do you know of a great paper that uses Probenecid from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Probenecid, supplier, ATP-binding, cassette, ABC, multidrug, resistance-associated, proteins, MRP, inhibitors, inhibits, Tocris Bioscience, Multidrug Transporter Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent P-glycoprotein (P-gp) inhibitorCeefourin 1
Selective MRP4 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.