Nicotinamide

Cat. No. 4106

Nicotinamide C6H6N2O [98-92-0]

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Chemical Name: Pyridine-3-carboxamide

Biological Activity

Anti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration.

Technical Data

M.Wt:
122.12
Formula:
C6H6N2O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
98-92-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Czubak et al (2014) A modified method of insulin producing cells' generation from bone marrow-derived mesenchymal stem cells. J.Diabetes Res. 2014 628591. PMID: 25405207.

Suzuki et al (2010) Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life.Sci. 86 676. PMID: 20188745.

Cimadamore et al (2009) Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells. 27 1772. PMID: 19544437.

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Keywords: Nicotinamide, supplier, Nicotinamide, inhibits, poly(ADP-ribose), polymerase-1, PARP-1, inhibitors, anti-inflammatory, organoids, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products

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