Cat. No. 4106
Chemical Name: Pyridine-3-carboxamide
Biological ActivityAnti-inflammatory agent. Inhibitor of poly(ADP-ribose) polymerase (PARP-1) enzymes. NAD+ precursor. Promotes differentiation of mesenchymal stem cells to insulin producing cells when used in combination with growth factors and high glucose concentration.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Czubak et al (2014) A modified method of insulin producing cells' generation from bone marrow-derived mesenchymal stem cells. J.Diabetes Res. 2014 628591. PMID: 25405207.
Suzuki et al (2010) Protective effect of nicotinamide against poly(ADP-ribose) polymerase-1-mediated astrocyte death depends on its transporter-mediated uptake. Life.Sci. 86 676. PMID: 20188745.
Cimadamore et al (2009) Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic cell death. Stem Cells. 27 1772. PMID: 19544437.
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Keywords: Nicotinamide, supplier, Nicotinamide, inhibits, poly(ADP-ribose), polymerase-1, PARP-1, inhibitors, anti-inflammatory, organoids, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products