Cat. No. 4102
Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-
Biological ActivityImmunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA (a reversible inhibitor of inosine monophosphate dehydrogenase). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Roos et al (2007) In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil. J.Pharm.Exp.Ther. 321 583.
Allison and Eugui (1996) Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin.Transplant. 10 77. PMID: 8680053.
If you know of a relevant reference for Mycophenolate mofetil please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Mycophenolate mofetil from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Mycophenolate mofetil, supplier, immunosuppressant, pro-drug, MMF, inhibits, inosine, monophosphate, dehydrogenase, Tocris Bioscience, Other Dehydrogenase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective ALDH1A1 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.