Mycophenolate mofetil

Cat. No. 4102

Mycophenolate mofetil C23H31NO7 [128794-94-5]

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Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester

Biological Activity

Immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA (a reversible inhibitor of inosine monophosphate dehydrogenase). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression.

Technical Data

M.Wt:
433.49
Formula:
C23H31NO7
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
128794-94-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Roos et al (2007) In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil. J.Pharm.Exp.Ther. 321 583.

Allison and Eugui (1996) Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin.Transplant. 10 77. PMID: 8680053.

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Keywords: Mycophenolate mofetil, supplier, immunosuppressant, pro-drug, MMF, inhibits, inosine, monophosphate, dehydrogenase, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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