SU 11274

Cat. No. 4101

SU 11274 C28H30ClN5O4S [658084-23-2]

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Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide

Biological Activity

Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.

Technical Data

M.Wt:
568.09
Formula:
C28H30ClN5O4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
658084-23-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Seiwert et al (2009) The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res. 69 3021. PMID: 19318576.

Sattler et al (2003) A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. Cancer Res. 63 5462. PMID: 14500382.

Wang et al (2003) Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth. Mol.Cancer Ther. 2 1085. PMID: 14617781.

If you know of a relevant reference for SU 11274 please let us know.

Citations are publications that use Tocris products. Selected citations for SU 11274 include:

Jiang et al (2015) YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells. Blood 13 280. PMID: 26310485.

Shibasaki et al (2014) Differential regulation of c-Met signaling pathways for synovial cell function. J Transl Med 3 554. PMID: 25332857.

Boyd et al (2013) Dissecting the role of human embryonic stem cell-derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in three-dimensional environments. Tissue Eng Part A 19 211. PMID: 22971005.

Dai et al (2012) Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells. J Biol Chem 287 14586. PMID: 22418436.

Sullivan et al (2012) ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Springerplus 8 646. PMID: 22660439.

Do you know of a great paper that uses SU 11274 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: SU 11274, supplier, SU11274, Supplier, c-Met, inhibitors, inhibits, MET, tyrosine, kinase, activity, met, receptors, Tocris Bioscience, MET Receptor Inhibitor products

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