Cat. No. 4098
Alternative Name: CBZ
Chemical Name: 5H-Dibenz[b,f]azepine-5-carboxamide
Biological ActivityInhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov.. PMID: 28529316.
Lipkind and Fozzard (2010) Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol.Pharmacol. 78 631. PMID: 20643904.
Sarkar et al (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16 46. PMID: 18636076.
Afanas'ev et al (1999) Lamotrigine and carbamazepine affect differently the release of D-[3H] aspartate from mouse cerebral cortex slices: involvement of NO. Neurochem.Res. 24 1153. PMID: 10485587.
Granger et al (1995) Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin. Mol.Pharmacol. 47 1189. PMID: 7603459.
If you know of a relevant reference for Carbamazepine please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Carbamazepine from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Carbamazepine, supplier, sodium, Na+, channels, GABAA, ligands, inhibits, inhibitors, anticonvulsants, CBZ, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products