Carbamazepine

Cat. No. 4098

Carbamazepine C15H12N2O [298-46-4]

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Alternative Name: CBZ

Chemical Name: 5H-Dibenz[b,f]azepine-5-carboxamide

Biological Activity

Inhibitor of neuronal voltage-gated Na+ channels. Exhibits anticonvulsant activity. Potentiates GABA-induced Cl- currents in HEK 293 cells expressing the GABAA receptor α1β2γ2 subtype combination. Can induce autophagy by inhibiting inositol synthesis.

Technical Data

M.Wt:
236.27
Formula:
C15H12N2O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
298-46-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lipkind and Fozzard (2010) Molecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore. Mol.Pharmacol. 78 631. PMID: 20643904.

Sarkar et al (2009) Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies. Cell Death Differ. 16 46. PMID: 18636076.

Afanas'ev et al (1999) Lamotrigine and carbamazepine affect differently the release of D-[3H] aspartate from mouse cerebral cortex slices: involvement of NO. Neurochem.Res. 24 1153. PMID: 10485587.

Granger et al (1995) Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin. Mol.Pharmacol. 47 1189. PMID: 7603459.

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Keywords: Carbamazepine, supplier, sodium, Na+, channels, GABAA, ligands, inhibits, inhibitors, anticonvulsants, CBZ, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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