Cat. No. 4096
Alternative Name: CLT
Chemical Name: 1-(2-Chloro-α,α-diphenylbenzyl)imidaz
Biological ActivityImidazole antimycotic and cytochrome P450 inhibitor. Inhibits Ca2+-activated K+ current (IC50 = 3 μM) and L-type Ca2+ current; increases the firing rate of action potentials. Exhibits antiproliferative activity in vitro and in vivo. Also an inverse agonist of the human constitutive androstane receptor (hCAR).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lempiainen et al (2005) Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol.Endocrinol. 19 2258. PMID: 15905360.
Thomas et al (1999) The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. Br.J.Pharmacol. 126 1531. PMID: 10323582.
Wu et al (1999) Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells. Neuropharmacology 38 979. PMID: 10428416.
Snajdrova et al (1998) Clomitrazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle. J.Biol.Chem. 273 28032. PMID: 9774419.
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Keywords: Clotrimazole, supplier, inhibits, calcium-activated, potassium, channels, Ca2+-activated, K+, channels, inhibitors, antifungal, antimycotic, cytochrome, P450, oxidase, Tocris Bioscience, Cytochrome P450 Inhibitor products
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