Amiodarone hydrochloride

Cat. No. 4095

Amiodarone hydrochloride C25H29I2NO3.HCl [19774-82-4]

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Chemical Name: 2-Butyl-3-benzofuranyl-4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride

Biological Activity

Broad-spectrum ion channel blocker; blocks late INa, ICa, IKr and IKs and increases QT. Displays class III antiarrhythmic properties. Also exhibits fungicidal activity; elicits Ca2+ influx in Saccharomyces cerevisiae and causes mitochondrial fragmentation and cell death. Thought to stimulate autophagy by targeting upstream mTORC1 control pathways. Selectively toxic to NSCs in hESC-derived cell populations.

Technical Data

Soluble to 50 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Balgi et al (2009) Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One 4 e7124. PMID: 19771169.

Han et al (2009) Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 4 7155. PMID: 19774075.

Antzelevitch et al (2004) Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 110 904. PMID: 15302796.

di Matola et al (2000) Amiodarone induces cytochrome c release and apoptosis through an iodine-dependent mechanism. J.Clin.Endocrin.Metab. 85 4323. PMID: 11095475.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Amiodarone hydrochloride include:

Turker et al (2013) Amiodarone inhibits apamin-sensitive potassium currents. PLoS One 8 e70450. PMID: 23922993.

Do you know of a great paper that uses Amiodarone hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Amiodarone hydrochloride, supplier, ion, channels, antagonists, blockers, INa, ICa, IKr, IKs, antiarrhythmic, class, III, Tocris Bioscience, Other Channel Modulator products

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