Cat. No. 4092
Chemical Name: 2-Acetoxybenzoic acid
Biological ActivityInhibitor of cyclooxygenase (COX)-1. Blocks the production of prostaglandins and thromboxanes. Exhibits antiplatelet and antithrombotic activities. Displays anticancer effects in some solid tumors. One of the first described NSAID drugs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Schror (1997) Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin.Thromb.Hemost. 23 349. PMID: 9263351.
Baron (1995) Aspirin and cancer. Preventative Medicine 24 121.
Sanduja et al (1991) Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells. Proc.Natl.Acad.Sci. 15 88.
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Citations are publications that use Tocris products. Selected citations for Aspirin include:
Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249. PMID: 24258815.
Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178. PMID: 24494191.
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Keywords: Aspirin, supplier, cyclooxygenase, inhibitors, inhibits, antithrombotic, antiplatelet, NSAID, prostaglandin, H, synthase, blocks, thromboxane, synthesis, Tocris Bioscience, Cyclooxygenase Inhibitor products
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