Aspirin

Cat. No. 4092

Aspirin C9H8O4 [50-78-2]

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Chemical Name: 2-Acetoxybenzoic acid

Biological Activity

Inhibitor of cyclooxygenase (COX)-1. Blocks the production of prostaglandins and thromboxanes. Exhibits antiplatelet and antithrombotic activities. Displays anticancer effects in some solid tumors. One of the first described NSAID drugs.

Technical Data

M.Wt:
180.16
Formula:
C9H8O4
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
50-78-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Schror (1997) Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin.Thromb.Hemost. 23 349. PMID: 9263351.

Baron (1995) Aspirin and cancer. Preventative Medicine 24 121.

Sanduja et al (1991) Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells. Proc.Natl.Acad.Sci. 15 88.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Aspirin include:

Mitrugno et al (2014) A novel and essential role for FcγRIIa in cancer cell-induced platelet activation. Blood 123 249. PMID: 24258815.

Walsh et al (2014) The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation. Redox Biol 2 178. PMID: 24494191.

Do you know of a great paper that uses Aspirin from Tocris? If so please let us know.

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Keywords: Aspirin, supplier, cyclooxygenase, inhibitors, inhibits, antithrombotic, antiplatelet, NSAID, prostaglandin, H, synthase, blocks, thromboxane, synthesis, Tocris Bioscience, Cyclooxygenase Inhibitor products

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