Cat. No. 4090
Chemical Name: (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethyl
Biological ActivityBroad-spectrum antibiotic and MMP inhibitor; tetracycline derivative. Increases and promotes smooth muscle cell adhesion; inhibits proliferation and migration. Protects the microvasculature by inhibiting plasminogen systems.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Wernig et al (2008) A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat.Biotechnol. 26 916. PMID: 18594521.
Burggraf et al (2007) Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol.Dis. 25 506. PMID: 17166729.
Franco et al (2006) Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am.J.Pathol. 168 1697. PMID: 16651635.
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Citations are publications that use Tocris products. Selected citations for Doxycycline hyclate include:
Kalous et al (2012) Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. J Neurochem 122 523. PMID: 22621370.
Do you know of a great paper that uses Doxycycline hyclate from Tocris? If so please let us know.
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Keywords: Doxycycline hyclate, supplier, tetracycline, antibiotics, inhibits, MMPs, matrix, metalloprotease, metalloproteinase, inhibitors, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
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