Cat. No. 4089
Chemical Name: 3'-[α-Amino-p-methoxyhydrocinnamamido
Biological ActivityProtein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction. Biochim.Biophys.Acta. 1150 89. PMID: 8334141.
Azzam and Algranati (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes. Proc.Nat.Acad.Sci. 70 3866.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Puromycin dihydrochloride include:
Zhu et al (2015) All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation. J Neurosci 10 e0143255. PMID: 26571119.
Do you know of a great paper that uses Puromycin dihydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Puromycin dihydrochloride, supplier, Puromycin, antibiotics, protein, synthesis, inhibitors, inhibits, translation, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.