Cat. No. 4084

LPYFD-NH2 Leu-Pro-Tyr-Phe-Asp-NH2

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Biological Activity

Neuroprotective peptide that binds to amyloid beta (Aβ). Protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. Potential therapeutic in the treatment of Alzheimer's Disease.

Technical Data


(Modifications: Asp-5 = C-terminal amide)

Soluble to 2 mg/ml in 10% acetonitrile / water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Juhasz et al (2009) An intraperitoneally administered pentapeptide protects against Aβ (1-42) induced neuronal excitation in vivo. J.Alzheimer's Dis. 16 189.

Szegedi et al (2005) Pentapeptides derived from Aβ1-42 protect neurons from the modulatory effects of Aβ fibrils- an in vitro and in vivo electrophysiological study. Neurobiology of Disease 18 499. PMID: 15755677.

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Citations are publications that use Tocris products.

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Keywords: LPYFD-NH2, supplier, LPYFDNH2, neuroprotective, amyloid, sequence-derived, peptides, binds, amyloid, beta, Ab, Aβ, Alzheimers, amyloidbeta, amyloidb, amyloidβ, Tocris Bioscience, Amyloid β Peptide products

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