PF 8380

Cat. No. 4078

PF 8380 C22H21Cl2N3O5 [1144035-53-9]

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Chemical Name: 3,5-Dichlorobenzyl-[4-[3-oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]]piperazine-1-carboxylate

Biological Activity

Potent autotaxin inhibitor (IC50 = 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levels in vivo and in vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Orally available.

Technical Data

Soluble to 100 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jankowski (2011) Autotaxin: its role in biology of melanoma cells and as a pharmacological target. Enzyme Res. 194857. PMID: 21423677.

Gierse et al (2010) A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. J.Pharmacol.Exp.Ther. 334 310. PMID: 20392816.

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Keywords: PF 8380, supplier, PF8380, pfizer, autotaxin, lysophospholipase, d, inhibitors, lysophosphatidic, acid, LPA, inhibits, potent, Tocris Bioscience, Autotaxin Inhibitor products

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