SNS 032

Cat. No. 4075

SNS 032 C17H24N4O2S2 [345627-80-7]

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Alternative Name: BMS-387032

Chemical Name: N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide

Biological Activity

Potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). Displays no activity against 190 additional kinases (IC50 >1000 nM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

Technical Data

M.Wt:
380.53
Formula:
C17H24N4O2S2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
345627-80-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Chen et al (2010) Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res. 70 6587. PMID: 20663900.

Conroy et al (2009) SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples. Cancer Chemother.Pharmacol. 64 723. PMID: 19169685.

Ali et al (2007) SNS-032 prevents tumor cell-induced angiogenesis by inhibiting vascular endothelial growth factor. Neoplasia 9 370. PMID: 17534442.

Misra et al (2004) N-(Cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent. J.Med.Chem. 47 1719. PMID: 15027863.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SNS 032 include:

Zhang et al (2015) Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1. PLoS One 89 4598. PMID: 25673708.

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Keywords: SNS 032, supplier, SNS032, inhibits, cyclin-depndent, kinase, Cdk, potent, inhibitors, cdk2, cdk7, cdk9, BMS387032, BMS, 387032, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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