YK 4-279

Cat. No. 4067

YK 4-279 C17H13Cl2NO4 [1037184-44-3]

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Chemical Name: 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indol-2-one

Biological Activity

Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Erkizan et al (2009) Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits Ewing's sarcoma. Nat.Med. 15 750. PMID: 19584866.

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Keywords: YK 4-279, supplier, YK4-279, inhibits, RNA, helicase, A, inhibitors, Ewing's, sarcoma, familty, tumor, ESFT, EWS-FLI1, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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