TC-A 2317 hydrochloride
Cat. No. 4066
Chemical Name: 2-[(5-Hydroxy-1,5-dimethylhexyl)ami
Biological ActivityPotent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM for inhibition of Aurora kinase B). Selective over 60 other kinases (IC50 values > 1000 nM). Exhibits good cell permeability and antitumor activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ando et al (2010) 3-Cyano-6-(-5-methyl-3-pyrazoloamino)pyridines: Selective Aurora A kinase inhibitors. Bioorg.Med.Chem.Lett. 20 4709. PMID: 20573509.
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Keywords: TC-A 2317 hydrochloride, supplier, inhibits, aurora, kinase, a, inhibitors, antitumor, Aurora, A, Tocris Bioscience, Aurora Kinase Inhibitor products
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