Fluorobexarotene

Cat. No. 4064

Fluorobexarotene C24H27FO2 [1190848-23-7]

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Chemical Name: 2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

Biological Activity

RXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors). Displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene.

Licensing Information

Manufactured and sold under license from Arizona State University - Patent Pending

Technical Data

M.Wt:
366.47
Formula:
C24H27FO2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>97 %
Storage:
Store at +4°C
CAS No:
1190848-23-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wagner et al (2009) Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J.Med.Chem. 52 5950. PMID: 19791803.

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Keywords: Fluorobexarotene, supplier, Fluorobexarotene, retinoid, x, rexinoids, rxr, agonists, Tocris Bioscience, Retinoid X Receptor Agonist products

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