Cat. No. 4064
Chemical Name: 2-Fluoro-4-[1-(5-,6,7,8-tetrahydro-
Biological ActivityRXR agonist (Ki = 12 nM; EC50 = 43 nM at RXRα receptors). Displays similar RAR agonist activity to bexarotene; exhibits an apparent RXR binding affinity 75% greater than bexarotene.
Licensing InformationManufactured and sold under license from Arizona State University - Patent Pending
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wagner et al (2009) Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). J.Med.Chem. 52 5950. PMID: 19791803.
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Citations are publications that use Tocris products.
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Keywords: Fluorobexarotene, supplier, Fluorobexarotene, retinoid, x, rexinoids, rxr, agonists, Tocris Bioscience, Retinoid X Receptor Agonist products
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