Cat. No. 4063
Chemical Name: 5-(4-Chlorophenyl)-1-(2,4-dichlorop
Biological ActivityPotent and selective CB1 receptor antagonist (Ki = 27.2 pM, IC50 = 118.9 pM for rat CB1 receptors). Exhibits potency in obesity and hyperlipidemia models; inhibits food intake and increases in body weight in diet-induced obese rats and mice.
Licensing InformationSold under licence.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Chen et al (2010) Novel, selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur.J.Pharmacol. 637 178. PMID: 20380831.
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Citations are publications that use Tocris products. Selected citations for MJ 15 include:
Kong et al (2016) Cannabinoid WIN-55,212-2 mesylate inhibits ADAMTS-4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan-1. J Virol 13 4569. PMID: 27082728.
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Keywords: MJ 15, supplier, MJ15, CB1, receptors, antagonist, cannabinoid, receptors, 1, antagonists, obesity, dyslipidemia, dyslipidaemia, Tocris Bioscience, CB1 Receptor Antagonist products
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November 12 - 16, 2016
San Diego, CA, USA