6-Thioguanine

Cat. No. 4061

6-Thioguanine C5H5N5S [154-42-7]

Price and Availability

For 6-Thioguanine pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: 6-TG

Chemical Name: 2-Amino-6-mercaptopurine

Biological Activity

Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1).

Technical Data

M.Wt:
167.19
Formula:
C5H5N5S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
154-42-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yuan et al (2011) 6-thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1. Cancer Res. 71 1904. PMID: 21239472.

Issaeva et al (2010) 6-Thioguanine selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance. Cancer Res. 70 6268. PMID: 20631063.

Wang and Wang (2009) 6-Thioguanine perturbs cytosine methylation at CgP dinucleotide site by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. Biochemistry 48 2290. PMID: 19236003.

If you know of a relevant reference for 6-Thioguanine please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses 6-Thioguanine from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: 6-Thioguanine, supplier, 6-TG, anticancer, chemotherapeutics, immunosupprressive, agents, cytotoxic, antineoplastic, cancer, BRCA2, tumors, epigenetics, antimetabolites, Tocris Bioscience, Immunosuppressant products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

New Products in this Area

NITD 008

Antiviral; selective flavivirus inhibitor

Nanchangmycin

Antiviral; active against Zika, West Nile and dengue viruses

25-Hydroxycholesterol

Antiviral; also α-crystallin (cryAB) chaperone

Filipin III

Polyene antibiotic; inhibits formation of pathological isoform of prion protein

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.