LY 78335

Cat. No. 4060

LY 78335 C8H9Cl2N.HCl [39959-66-5]

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Chemical Name: 2,3-Dichloro-α-methylbenzylamine hydrochloride

Biological Activity

High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.

Technical Data

Soluble to 100 mM in water with gentle warming and to 100 mM in DMSO with gentle warming
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Grunewald et al (1988) Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 31 824. PMID: 3351861.

Terry et al (1982) Regulation of episodic growth hormone secretion by the central epinephrine system. J.Clin.Invest. 69 104. PMID: 7054231.

Fuller et al (1973) Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 16 106. PMID: 4683104.

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Keywords: LY 78335, supplier, LY78335, phenylethanolamine-N-methyltransferase, PNMT, high, affinity, inhibitors, inhibits, methyltransferases, Tocris Bioscience, Other Transferase Inhibitor products

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