Cat. No. 4058
Biological ActivityPseudosubstrate peptide inhibitor of protein kinase C (IC50 = 0.18 μM). Attenuates vascular hyperproliferation and hypertrophy induced by high glucose. Inhibits DNA and protein synthesis in vascular smooth muscle cells (VSMCs) in a dose-dependent manner. Inactive control available ([Glu27]-PKC (19-36), Cat. No. 4059).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Yasunari et al (1996) Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration Hypertension 28 159. PMID: 8707376.
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Citations are publications that use Tocris products. Selected citations for PKC (19-36) include:
Glovaci and Chapman (2015) Activation of Phosphatidylinositol-Linked Dopamine Receptors Induces a Facilitation of Glutamate-Mediated Synaptic Transmission in the Lateral Entorhinal Cortex. Mol Med Rep 10 e0131948. PMID: 26133167.
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Keywords: PKC (19-36), supplier, PKC, inhibitors, inhibits, pseudosubstrate, protein, kinase, C, fragment, (19-36), PKCI, Tocris Bioscience, Protein Kinase C Inhibitor products
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