Cat. No. 4055
Alternative Names: L-Ascorbate, Vitamin C
Chemical Name: 3-Oxo-L-gulofuranolactone
Biological ActivityInhibitor of Cav3.2 channels (IC50 = 6.5 μM); displays no effect on Cav3.1 or Cav3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Naturally occurring antioxidant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Esteban et al (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6 71. PMID: 20036631.
Nelson et al (2007) Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J.Neurosci. 27 12577. PMID: 18003836.
Padayatty et al (2003) Vitamin C as an antioxidant: evaluation of its role in disease prevention. J.Am.Coll.Nutr. 22 18. PMID: 12569111.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for L-Ascorbic acid include:
Shahraz et al (2015) Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages. Cell Rep 5 16800. PMID: 26582367.
Lu et al (2013) Generation of integration-free and region-specific neural progenitors from primate fibroblasts. BMC Dev Biol 3 1580. PMID: 23643533.
Yeligar et al (2009) Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol 183 5232. PMID: 19783678.
Do you know of a great paper that uses L-Ascorbic acid from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: L-Ascorbic acid, supplier, L-Ascorbic, acid, Vc, vitamin, C, ascorbate, calcium, channels, t-type, CaV3.2, selective, Ca2+, channel, blockers, voltage-gated, voltage-dependent, iPSC, stem, cells, Tocris Bioscience, Reprogramming products
Find multiple products by catalog number
New Products in this Area
Oct4 activator; enhances iPSC reprogramming efficiencyNSC 23005 sodium
Potently promotes HSC expansion ; p18INK inhibitorAS 8351
Induces reprogramming of fibroblasts into functional cardiomyocytes
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.