Cat. No. 4055
Alternative Names: L-Ascorbate, Vitamin C
Chemical Name: 3-Oxo-L-gulofuranolactone
Biological ActivityInhibitor of Cav3.2 channels (IC50 = 6.5 μM); displays no effect on Cav3.1 or Cav3.3 channels heterologously expressed in HEK 293 cells. Also enhances the generation of induced pluripotent stem cells (iPSCs) from mouse and human somatic cells by increasing reprogramming efficiency. Naturally occurring antioxidant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Esteban et al (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6 71. PMID: 20036631.
Nelson et al (2007) Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J.Neurosci. 27 12577. PMID: 18003836.
Padayatty et al (2003) Vitamin C as an antioxidant: evaluation of its role in disease prevention. J.Am.Coll.Nutr. 22 18. PMID: 12569111.
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Citations are publications that use Tocris products. Selected citations for L-Ascorbic acid include:
Shahraz et al (2015) Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages. Cell Rep 5 16800. PMID: 26582367.
Lu et al (2013) Generation of integration-free and region-specific neural progenitors from primate fibroblasts. BMC Dev Biol 3 1580. PMID: 23643533.
Yeligar et al (2009) Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol 183 5232. PMID: 19783678.
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Keywords: L-Ascorbic acid, supplier, L-Ascorbic, acid, Vc, vitamin, C, ascorbate, calcium, channels, t-type, CaV3.2, selective, Ca2+, channel, blockers, voltage-gated, voltage-dependent, iPSC, stem, cells, Tocris Bioscience, Reprogramming products
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