BMS 470539 dihydrochloride

Cat. No. 4053

BMS 470539 dihydrochloride C32H41N5O4.2HCl [457893-92-4]

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Chemical Name: 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride

Biological Activity

Potent, selective melanocortin MC1 receptor agonist (IC50 = 120 nM). Exhibits anti-inflammatory properties following ischemia-reperfusion in the vasculature. Inhibits leukocyte trafficking.

Technical Data

M.Wt:
632.62
Formula:
C32H41N5O4.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
457893-92-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Leoni et al (2010) The melanocortin MC1 receptor agonist BMS-470539 inhibits leukocyte trafficking in the inflamed vasculature. Br.J.Pharmacol. 160 171. PMID: 20331604.

Kang (2006) A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice. J.Leukoc.Biol. 80 897. PMID: 16888084.

Herpin et al (2003) Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J.Med.Chem. 46 1123. PMID: 12646021.

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Keywords: BMS 470539 dihydrochloride, supplier, BMS470539, melanocortin, agonist, MC1, agonists, anti-inflammatory, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products

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