8-Aminoadenine

Cat. No. 4050

8-Aminoadenine C5H6N6 [28128-33-8]

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Chemical Name: 9H-Purine-6,8-diamine

Biological Activity

Adenine receptor agonist (Ki = 0.0341 μM in HEK293 cells expressing an adenine binding site). Displays 190-fold increased potency at the human binding site over the rat adenine receptor (rAde1R) (Ki = 6.51 μM).

Technical Data

M.Wt:
150.14
Formula:
C5H6N6
Solubility:
Soluble to 100 mM in 2eq.HCl and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
28128-33-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Borrmann et al (2009) Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J.Med.Chem. 52 5974. PMID: 19731917.

Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573.

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Keywords: 8-Aminoadenine, supplier, p0, adenine, receptors, agonists, purinergic, signaling, signalling, Tocris Bioscience, Adenine Receptor Agonist products

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P2 Receptors Review

Written by Kenneth Jacobson

P2X and P2Y Receptors Scientific Review

Our Purine Receptor review gives an overview of the subtypes and structures of the P2 receptor family, and the pharmacological ligands used to study them. Request copy or view PDF today.

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