Cat. No. 4050
Chemical Name: 9H-Purine-6,8-diamine
Biological ActivityAdenine receptor agonist (Ki = 0.0341 μM in HEK293 cells expressing an adenine binding site). Displays 190-fold increased potency at the human binding site over the rat adenine receptor (rAde1R) (Ki = 6.51 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Borrmann et al (2009) Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. J.Med.Chem. 52 5974. PMID: 19731917.
Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573.
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Citations are publications that use Tocris products.
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Keywords: 8-Aminoadenine, supplier, p0, adenine, receptors, agonists, purinergic, signaling, signalling, Tocris Bioscience, Adenine Receptor Agonist products
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