BINA

Cat. No. 4048

BINA C30H30O4 [866823-73-6]

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Alternative Name: Biphenyl-indanone A

Chemical Name: 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid

Biological Activity

Selective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Displays no effect on glutamate-induced activation of other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.

Technical Data

M.Wt:
454.56
Formula:
C30H30O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
866823-73-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Benneyworth et al (2007) A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol.Pharmacol. 72 477. PMID: 17526600.

Galici et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J.Pharmacol.Exp.Ther. 318 173. PMID: 16608916.

Bonnefous et al (2005) Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg.Med.Chem.Lett. 15 4354. PMID: 16046122.

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Keywords: BINA, supplier, pam, positive, allosteric, modulators, metabotropic, glutamate, receptors, mglu2, group, II, selective, biphenyl-indanone, A, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products

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