Cat. No. 4048
Alternative Name: Biphenyl-indanone A
Chemical Name: 3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-
Biological ActivitySelective positive allosteric modulator of mGlu2 (EC50 = 33.2 nM in CHO cells expressing human mGlu2). Displays no effect on glutamate-induced activation of other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Benneyworth et al (2007) A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol.Pharmacol. 72 477. PMID: 17526600.
Galici et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J.Pharmacol.Exp.Ther. 318 173. PMID: 16608916.
Bonnefous et al (2005) Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg.Med.Chem.Lett. 15 4354. PMID: 16046122.
If you know of a relevant reference for BINA please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses BINA from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: BINA, supplier, pam, positive, allosteric, modulators, metabotropic, glutamate, receptors, mglu2, group, II, selective, biphenyl-indanone, A, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products
Find multiple products by catalog number
New Products in this Area
Stable photoreleaser of L-glutamateTASP 0433864
Selective mGlu2 receptor positive allosteric modulator
September 27 - 30, 2017