Terazosin hydrochloride

Cat. No. 1506

Terazosin hydrochloride C19H25N5O4.HCl [63074-08-8]

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Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride

Biological Activity

α1- and α2B-adrenoceptor antagonist (Ki values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo.

Technical Data

Soluble to 50 mM in water with gentle warming
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hancock et al (1995) Actions of terazosin and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro. J.Recept.Signal Transduct.Res. 15 863. PMID: 8673721.

Maruyama et al (1994) Comparison of displacemental potencies of terazosin enantiomers for α1-adrenoceptor subtypes. Biol.Pharm.Bull. 17 1126. PMID: 7820122.

Kyncl (1986) Pharmacology of terazosin. Am.J.Med. 80 12. PMID: 2872801.

If you know of a relevant reference for Terazosin hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Terazosin hydrochloride include:

Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128. PMID: 24714037.

Do you know of a great paper that uses Terazosin hydrochloride from Tocris? If so please let us know.

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Keywords: Terazosin hydrochloride, supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, α2B-adrenoceptor, alpha2B-adrenoceptor, a2b-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, a2a-adrenergic, alpha2a-adrenergic, antagonists, Orally, active, Receptors, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products

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