Cat. No. 1506
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazol
Biological Activityα1- and α2B-adrenoceptor antagonist (Ki values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hancock et al (1995) Actions of terazosin and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro. J.Recept.Signal Transduct.Res. 15 863. PMID: 8673721.
Maruyama et al (1994) Comparison of displacemental potencies of terazosin enantiomers for α1-adrenoceptor subtypes. Biol.Pharm.Bull. 17 1126. PMID: 7820122.
Kyncl (1986) Pharmacology of terazosin. Am.J.Med. 80 12. PMID: 2872801.
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Citations are publications that use Tocris products. Selected citations for Terazosin hydrochloride include:
Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128. PMID: 24714037.
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Keywords: Terazosin hydrochloride, supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, α2B-adrenoceptor, alpha2B-adrenoceptor, a2b-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, a2a-adrenergic, alpha2a-adrenergic, antagonists, Orally, active, Receptors, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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