Sipatrigine

Cat. No. 4044

Sipatrigine C15H16Cl3N5 [130800-90-7]

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Alternative Name: 619C89

Chemical Name: 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine

Biological Activity

Blocker of voltage-dependent sodium channels (NaV). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca2+ channels. Analog of lamotrigine (Cat. No. 1611).

Technical Data

M.Wt:
372.68
Formula:
C15H16Cl3N5
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
130800-90-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Stefani et al (1998) On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br.J.Pharmacol. 125 1058. PMID: 9846645.

Graham et al (1994) Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J.Pharmacol.Exp.Ther. 269 854. PMID: 7910213.

Leach et al (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 24 1063. PMID: 8100654.

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Keywords: Sipatrigine, supplier, nav, voltage-dependent, sodium, Na+, channels, blockers, neuroprotective, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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