PT 1

Cat. No. 4039

PT 1 C23H16ClN3O6S [331002-70-1]

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Chemical Name: 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid

Biological Activity

AMP-activated protein kinase (AMPK) activator. Stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Thought to directly activate AMPK by antagonizing autoinhibition.

Technical Data

M.Wt:
497.91
Formula:
C23H16ClN3O6S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1.1eq. NaOH
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
331002-70-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jensen et al (2015) PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain. Biochem.J. 467 461. PMID: 25695398.

Zorn and Wells (2010) Turning enzymes ON with small molecules. Nat.Chem.Biol. 6 179. PMID: 20154666.

Pang et al (2007) Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells. J.Biol.Chem. 283 16051.

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Citations are publications that use Tocris products.

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Keywords: PT 1, supplier, AMPK, amp-activated, protein, kinase, activators, PT1, Tocris Bioscience, AMPK Activator products

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