BRD 7389

Cat. No. 4037

BRD 7389 C24H18N2O2 [376382-11-5]

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Chemical Name: 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione

Biological Activity

Ribosomal S6 kinase (RSK) inhibitor (IC50 values are 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively). Upregulates insulin expression in terminally differentiated pancreatic α-cells.

Technical Data

M.Wt:
366.41
Formula:
C24H18N2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
376382-11-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Fomina-Yadlin et al (2010) Small molecule inducers of insulin expression in pancreatic alpha cells. Proc.Natl.Acad.Sci. USA 107 15099.

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Citations are publications that use Tocris products. Selected citations for BRD 7389 include:

Breindel et al (2013) EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 73 5053. PMID: 23794705.

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RSK

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Keywords: BRD 7389, supplier, BRD7389, p90, rsk, ribosomal, s6, kinases, inhibitors, inhibits, rsk1, rsk2, rsk3, Tocris Bioscience, RSK Inhibitor products

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