Mycophenolic acid

Cat. No. 1505

Mycophenolic acid C17H20O6 [24280-93-1]

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Chemical Name: 6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid

Biological Activity

Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo. Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.

Technical Data

M.Wt:
320.34
Formula:
C17H20O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
24280-93-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Goldberg et al (1998) Pharmacological characterization of endomorphin-1 and endomorphin-2 in mouse brain. J.Pharmacol.Exp.Ther. 286 1007. PMID: 9694962.

Chapman et al (1997) Distinct inhibitory effects of spinal endomorphin-1 and endomorphin-2 on evoked dorsal horn neuronal responses in the rat. Br.J.Pharmacol. 122 1537. PMID: 9422796.

Zadina et al (1997) A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386 499. PMID: 9087409.

Senda et al (1995) Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells. Transplantation 60 1143. PMID: 7482723.

Allison et al (1993) Mechanisms of action of mycophenolic acid. Ann.N.Y.Acad.Sci. 696 63. PMID: 7906496.

Eugui et al (1991) Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: role of deoxyguanosine nucleotide depeletion. Scand.J.Immunol. 33 161. PMID: 1826793.

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Citations are publications that use Tocris products. Selected citations for Mycophenolic acid include:

Gomez et al (2015) Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. PLoS One 10 e0133862. PMID: 26288179.

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Keywords: Mycophenolic acid, supplier, Inosine, monophosphatase, dehydrogenases, inhibitors, inhibits, immunosuppressant, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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