Cat. No. 4036
Alternative Names: 25-Hydroxyvitamin D3, Calcidiol
Chemical Name: (εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5
Biological ActivityProhormone of calcitriol (Cat. No. 2551). Major circulating form of vitamin D. Suppresses PTH synthesis and secretion in bovine parathyroid cells (ED50 = 2 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fedirko et al (2010) Blood 25-hydroxyvitamin D3 concentrations and incident sporadic colorectal adenoma risk: a pooled case-control study. Am.J.Epidemiol. 172 489. PMID: 20650953.
Ritter et al (2006) 25-hydroxyvitamin D3 suppresses PTH synthesis and secretion by bovine parathyroid cells. Kidney Int. 70 654. PMID: 16807549.
Rowling et al (2006) Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. J.Nutr. 136 2754. PMID: 17056796.
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Citations are publications that use Tocris products. Selected citations for Calcifediol include:
Kim et al (2014) Vitamin D Inhibits Expression and Activity of Matrix Metalloproteinase in Human Lung Fibroblasts (HFL-1) Cells. Biochim Biophys Acta 77 73. PMID: 25237378.
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Keywords: Calcifediol, supplier, major, circulating, forms, vitamin, D, cholecalciferol, 25-HydroxyvitaminD3, calcitriol, 1,25-DihydroxyvitaminD3, Tocris Bioscience, Vitamin D Receptor products