Cat. No. 4033

5'-Fluoroindirubinoxime C16H10FN3O2 [861214-33-7]

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Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime

Biological Activity

Inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

Licensing Information

Sold under licence from Anygen Co. Ltd.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Choi et al (2010) Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 20 2033. PMID: 20153646.

Krivogorsky et al (2008) Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 52 4466. PMID: 18824607.

Kim et al (2007) Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 13 253. PMID: 17200363.

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Citations are publications that use Tocris products.

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Keywords: 5'-Fluoroindirubinoxime, supplier, FMS-like, receptor, tyrosine, kinase-3, FLT3, inhibitors, inhibits, antiproliferative, 5-Fluoroindirubinoxime, Tocris Bioscience, FLT3 Inhibitor products

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