Cat. No. 4033
Chemical Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-
Biological ActivityInhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).
Licensing InformationSold under licence from Anygen Co. Ltd.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Choi et al (2010) Indiribuin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg.Med.Chem.Lett. 20 2033. PMID: 20153646.
Krivogorsky et al (2008) Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs. Antimicrob.Agents Chemother. 52 4466. PMID: 18824607.
Kim et al (2007) Antitumor activity of novel indirubin derivatives in rat tumor model. Clin.Cancer Res. 13 253. PMID: 17200363.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses 5'-Fluoroindirubinoxime from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: 5'-Fluoroindirubinoxime, supplier, FMS-like, receptor, tyrosine, kinase-3, FLT3, inhibitors, inhibits, antiproliferative, 5-Fluoroindirubinoxime, Tocris Bioscience, FLT3 Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective TrkB receptor agonist; neuroprotectantAV 412
Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinasesCP 724714
Potent and selective ErbB2 inhibitorMitoglitazone
Insulin sensitizer; exhibits low binding affinity at PPARγPF 6274484
High affinity and potent covalent EGFR kinase inhibitorCanertinib dihydrochloride
Potent EGFR kinase inhibitorCHMFL-FLT3-122
Potent and selective FLT3 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.