Ralfinamide mesylate

Cat. No. 4029

Ralfinamide mesylate C17H19FN2O2.CH3SO3H [202825-45-4]

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Chemical Name: (2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate

Biological Activity

Sodium channel blocker. Suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Antinociceptive; displays analgesic effects in animal models of inflammatory and neuropathic pain.

Technical Data

Soluble to 25 mM in water and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Zhang et al (2008) Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain 139 293. PMID: 18583049.

Yamane et al (2007) Effects of ralfinamide, a Na+ channel blocker, on firing properties of nociceptive dorsal root ganglion neurons of adult rats. Exp.Neurol. 208 63. PMID: 17707373.

Veneroni et al (2003) Anti-allodynic effect of NW-1029, a novel Na+ channel blocker, in experimental animal models of inflammatory and neuropathic pain. Pain 102 17. PMID: 12620593.

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Keywords: Ralfinamide mesylate, supplier, Ralfinamide, sodium, Na+, blockers, channels, NaV, tetrodotoxin, TTXr, TTXs, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

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