CCG 63802

Cat. No. 4028

CCG 63802 C26H18N4O2S [620112-78-9]

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Chemical Name: (2E)-2-(1,3-Benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl]acrylonitrile

Biological Activity

Reversible inhibitor of regulator of G-protein signaling (RGS) proteins. Selective amongst RGS proteins, with greatest potency at RGS4. Inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo. Retains activity under reducing conditions.

Technical Data

Soluble to 5 mM in DMSO with gentle warming
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Blazer et al (2010) Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol.Pharmacol. 78 524. PMID: 20571077.

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Citations are publications that use Tocris products. Selected citations for CCG 63802 include:

Taccola et al (2016) A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity. Experimental Neurology 286 1. PMID: 27641322.

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Keywords: CCG 63802, supplier, CCG63802, inhibitors, inhibits, regulator, g-protein, signaling, signalling, RGS, RGS4, G, proteins, Tocris Bioscience, G Protein (Heterotrimeric) Inhibitor products

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