GSK 1059615

Cat. No. 4026

GSK 1059615 C18H11N3O2S [958852-01-2]

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Chemical Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

Biological Activity

Potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
333.36
Formula:
C18H11N3O2S
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
958852-01-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39.

Saadia et al (2009) Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin.Cancer Res. 15 3029. PMID: 19383818.

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Keywords: GSK 1059615, supplier, Potent, inhibitors, inhibits, PI3Kα, PI3Ka, PI3Kalpha, PI3Kinasealpha, GSK1059615, PI3-kinases, phosphoinositide, 3, kinases, Tocris Bioscience, PI 3-kinase Inhibitor products

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