α-Amanitin

Cat. No. 4025

alpha-Amanitin C39H54N10O14S [23109-05-9]

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Chemical Name: cyclo[L-Asparaginyl-4-hydroxy-L-proly-(R-4,5-dihydroxy-L-isoleucyl-6-hydroxy-2-mercapto-L-tryptophylglycyl-L-isoleucylglycyl-L-cysteinyl]cyclic (4→8)-sulfide (R)-S-oxide

Biological Activity

Inhibitor of RNA polymerase II. Inhibits transcription in eukaryotic cells. Binds and blocks the largest subunits of RNA polymerase II, preventing new ribonucleotides from incorporating into the nascent RNA chain. Potent amatoxin.

Technical Data

M.Wt:
918.97
Formula:
C39H54N10O14S
Solubility:
Soluble to 5 mM in ethanol and to 5 mM in water
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
23109-05-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Raha et al (2010) Close association of RNA polymerase II and many transcription factors with Pol III genes. Proc.Natl.Acad.Sci. 107 3639.

Casse et al (1999) The transcriptional inhibitors, actinomycin D and α-amanitin, activate the HIV-1 promoter and favor phosphorylation of the RNA polymerase II C-terminal domain. J.Biol.Chem. 274 16097. PMID: 10347161.

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Keywords: alpha-Amanitin, supplier, alpha-Amanitin, a-Amanitin, α-Amanitin, RNA, polymerases, II, inhibitors, inhibits, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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