JNJ 7777120

Cat. No. 4021

JNJ 7777120 C14H16ClN3O [459168-41-3]

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Chemical Name: 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine

Biological Activity

Histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.

Licensing Information

Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Technical Data

Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Strakhova et al (2009) In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 157 44. PMID: 19413570.

Thurmond et al (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 309 404. PMID: 14722321.

Jablanowski et al (2003) The first potent and selective non-imidazole human histamine H4 receptor antagonists. J.Med.Chem. 46 3957. PMID: 12954048.

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Keywords: JNJ 7777120, supplier, JNJ7777120, histamine, 4, histaminergic, H4, receptors, antagonists, selective, Tocris Bioscience, Histamine H4 Receptor Antagonist products

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