Cat. No. 4021
Chemical Name: 1-[(5-Chloro-1H-indol-2-yl)carbonyl
Biological ActivityHistamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.
Licensing InformationSold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Strakhova et al (2009) In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 157 44. PMID: 19413570.
Thurmond et al (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 309 404. PMID: 14722321.
Jablanowski et al (2003) The first potent and selective non-imidazole human histamine H4 receptor antagonists. J.Med.Chem. 46 3957. PMID: 12954048.
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Keywords: JNJ 7777120, supplier, JNJ7777120, histamine, 4, histaminergic, H4, receptors, antagonists, selective, Tocris Bioscience, Histamine H4 Receptor Antagonist products