JNJ 5207787

Cat. No. 4018

JNJ 5207787 C32H38N4O2 [683746-68-1]

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Chemical Name: (2E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyanophenyl)-N-[1-(2-cyclopentylethyl)-4-piperidinyl]-2-propenamide

Biological Activity

Selective NPY Y2 antagonist (IC50 = 0.1 μM). Displays 100-fold selectivity over NPY Y1, Y4 and Y5 receptors; also displays selectivity against a panel of 50 receptors, ion channels and transporters. Brain penetrant.

Licensing Information

Sold with the permission of Janssen Pharmaceutica N.V.

Technical Data

M.Wt:
510.67
Formula:
C32H38N4O2
Solubility:
Soluble to 10 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
Purity:
>98 %
Storage:
Store at RT
CAS No:
683746-68-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bonaventure et al (2004) Characterization of N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-3-(3-cyano-phenyl)-N-[1-(2-cyclopentyl-ethyl)-piperidin-4yl]acrylamide (JNJ-5207787), a small molecule antagonist of the neuropeptide Y Y2 receptor. J.Pharmacol.Exp.Ther. 308 1130. PMID: 14617685.

Jablonowski et al (2004) Novel non-peptide neuropeptide Y Y2 receptor antagonists. Bioorg.Med.Chem.Lett. 14 1239. PMID: 14980673.

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Keywords: JNJ 5207787, supplier, JNJ5207787, neuropeptide, y, NPY, Y2, antagonists, selective, Tocris Bioscience, NPY Receptor Antagonist products

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