IDE 2

Cat. No. 4016

IDE 2 C12H20N2O3 [1136466-93-7]

Price and Availability

For IDE 2 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: Heptanedioic acid-1-(2-cyclopentylidenehydrazide)

Biological Activity

Cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro, and gut tube formation in vivo.

Licensing Information

Sold for research purpose under license from Harvard University.

Technical Data

M.Wt:
240.3
Formula:
C12H20N2O3
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1136466-93-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Filby et al (2011) Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res.Ther. 2 16. PMID: 21463501.

Borowniak et al (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4 348. PMID: 19341624.

Zaret (2009) Using small molecules to great effect in stem cell differentiation. Cell Stem Cell 4 373. PMID: 19427285.

If you know of a relevant reference for IDE 2 please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses IDE 2 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: IDE 2, supplier, IDE2, inducer, induces, endodermal, formation, embryonic, stem, cells, differentiation, ESCs, nodal, sox17, Tocris Bioscience, ESCs and iPSCs products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Stem Cell Toolbox

80 Stem Cell modulators supplied pre-dissolved in DMSO

Tocriscreen Stem Cell  Toolbox

Includes many of the latest compounds available for stem cell research. Covers compounds for stem cell differentiation, signaling and reprogramming.

divider line

Stem Cells Scientific Review

Written by K. Clarke et al

Stem Cells Scientific Review

Our Stem Cells review gives an overview of the use of small molecules in the control of stem cell growth & differentiation and somatic cell reprogramming. Request copy or view PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.