Cat. No. 4016
Chemical Name: Heptanedioic acid-1-(2-cyclopentylidenehydrazide
Biological ActivityCell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro, and gut tube formation in vivo.
Licensing InformationSold for research purpose under license from Harvard University.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Filby et al (2011) Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res.Ther. 2 16. PMID: 21463501.
Borowniak et al (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4 348. PMID: 19341624.
Zaret (2009) Using small molecules to great effect in stem cell differentiation. Cell Stem Cell 4 373. PMID: 19427285.
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Keywords: IDE 2, supplier, IDE2, inducer, induces, endodermal, formation, embryonic, stem, cells, differentiation, ESCs, nodal, sox17, Tocris Bioscience, ESCs and iPSCs products