MK 217

Cat. No. 4014

MK 217 C4H12NNaO7P2 [129318-43-0]

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Alternative Name: Alendronate sodium

Chemical Name: P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonic acid monosodium salt

Biological Activity

Osteoclast-mediated bone resorption inhibitor. Binds and blocks farnesyl diphosphate synthase (FPPS) in the HMG-CoA pathway (IC50 = 460 nM for recombinant human FPPS); causes macrophage apoptosis. Inhibits prenylation and sterol biosynthesis in purified osteoclasts.

Technical Data

Soluble to 50 mM in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fournier et al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vitro. Cancer Res. 68 8945. PMID: 18974139.

Bergstrom et al (2000) Alendronate is a specific, nanomolar inhibitor of fanesyl diphosphate synthase. Arch.Biochem.Biophys. 373 231. PMID: 10620343.

Fisher et al (1999) Alendronate mechanism of action; geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc.Natl.Acad.Sci. 96 133.

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Keywords: MK 217, supplier, MK217, osteoclasts, mediated, bone, resorption, osteoporosis, inhibits, farnesyl, diphosphate, synthase, inhibitors, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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