Cat. No. 4012
Chemical Name: 1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1
Biological ActivityPotent NK1 receptor antagonist (Ki = 0.74 nM. IC50 = 1.6 nM). Inhibits substance P-invoked calcium mobilization and outward current (IC50 = 1.3 nM); blocks NK1-mediated nitric oxide-dependent vasodilation in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Nieuwmeyer et al (2006) Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of Cajal. J.Pharmacol.Exp.Ther. 317 439. PMID: 16330493.
Hall and Brain (1994) Inhibition by SR140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilation in the hamster cheek pouch microvasculature in vivo. Br.J.Pharmacol. 113 522. PMID: 7530573.
Oury-Donat et al (1994) SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line. J.Neurochem. 62 1399. PMID: 7510780.
Emonds-Alt et al (1993) In vitro and in vivo biological activities of SR140333, a novel non-peptide tachykinin NK1 receptor antagonist. Eur.J.Pharmacol. 250 403. PMID: 7509286.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SR 140333 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SR 140333, supplier, SR140333, neurokinin1, nk1, tachykinins, receptor, antagonists, potent, Tocris Bioscience, NK1 Receptor Antagonist products
Find multiple products by catalog number
April 1 - 5, 2017
Washington, D.C., USA