Cat. No. 4011
Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-te
Biological ActivityPhotostable synthetic retinoid; analog of ATRA (Cat. No. 0695). Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Potently induces neural differentiation in human pluripotent embryonic stem cells.
Licensing InformationSold under license from Reinnervate Limited, patent pending
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Barnard et al (2009) Synthetic retinoids: structure-activity relationships. Chemistry 15 11430. PMID: 19821467.
Maltman et al (2009) Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol.Biosyst. 5 458. PMID: 19381361.
Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497. PMID: 19082150.
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Citations are publications that use Tocris products.
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Keywords: EC 23, supplier, retinoids, synthetic, stem, cells, induces, differentiation, ATRA, retinoic, acid, receptors, agonists, EC23, Tocris Bioscience, Retinoic Acid Receptor products
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