EC 23

Cat. No. 4011

EC 23 C23H24O2 [104561-41-3]

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Chemical Name: 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid

Biological Activity

Photostable synthetic retinoid; analog of ATRA (Cat. No. 0695). Displays similar activity to ATRA when tested on the embryonal carcinoma stem cell model TERA2.cl.SP12. Potently induces neural differentiation in human pluripotent embryonic stem cells.

Licensing Information

Sold under license from Reinnervate Limited, patent pending

Technical Data

M.Wt:
332.44
Formula:
C23H24O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
104561-41-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Barnard et al (2009) Synthetic retinoids: structure-activity relationships. Chemistry 15 11430. PMID: 19821467.

Maltman et al (2009) Proteomic profiling of the stem cell response to retinoic acid and synthetic retinoid analogues: identification of major retinoid-inducible proteins. Mol.Biosyst. 5 458. PMID: 19381361.

Christie et al (2008) Synthesis and evaluation of synthetic retinoid derivatives as inducers of stem cell differentiation. Org.Biomol.Chem. 6 3497. PMID: 19082150.

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Keywords: EC 23, supplier, retinoids, synthetic, stem, cells, induces, differentiation, ATRA, retinoic, acid, receptors, agonists, EC23, Tocris Bioscience, Retinoic Acid Receptor products

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