Cat. No. 4005
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-2,6-
Biological ActivityActivator of aldehyde dehydrogenase 2 (ALDH2). Increases activity of wild-type ALDH2*1 and variant ALDH2*2 (by ~2-fold and 11-fold respectively). Capable of partly restoring mutant ALDH2*2 activity; protective against cardiac ischemia.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Beretta et al (2010) Characterization of the East Asian variant of aldehyde dehydrogenase-2. Bioactivation of nitroglycerin and effects of alda-1. J.Biol.Chem. 285 943. PMID: 19906643.
Chen et al (2008) An activator of mutant and wildtype aldehyde dehydrogenase reduces ischemic damage to the heart. Science 321 1493. PMID: 18787169.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Alda 1 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Alda 1, supplier, aldehyde, dehydrogenases, activators, aldh2, aldh2*1, aldh2*2, aldh22, aldh21, cardiac, ischemia, Alda1, Tocris Bioscience, Aldehyde Dehydrogenase Activator products