LDN 57444

Cat. No. 3998

LDN 57444 C17H11Cl3N2O3 [668467-91-2]

Price and Availability

For LDN 57444 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)

Biological Activity

Inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) activity (Ki = 0.4 μM). Causes cell death through the apoptosis pathway; increases levels of highly ubiquitinated proteins and decreases ubiquitin proteasome activity. Activity leads to dramatic alterations in synaptic protein distribution and spine morphology in vivo.

Technical Data

M.Wt:
397.64
Formula:
C17H11Cl3N2O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
668467-91-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cartier et al (2009) Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J.Neurosci. 29 7857. PMID: 19535597.

Tan et al (2008) Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318 109. PMID: 18622688.

Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837. PMID: 14522054.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses LDN 57444 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: LDN 57444, supplier, LDN57444, UCH, L1, inhibitors, inhibits, ubiquitin, C-terminal, hydrolases, UCH-L1, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

Ritonavir

HIV-1 and HIV-2 protease inhibitor

Acetyl Pepstatin

High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases

ONO 6818

High affinity and selective human neutraphil elastase 1 (HNE1) inhibitor; orally active

TM 5275 sodium salt

Plasminogen activator inhibitor-1 (PAI-1) inhibitor; orally bioavailable

Sacubitril calcium

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable

PF 3084014 hydrobromide

Potent γ-secretase inhibitor

Z-VRPR-FMK trifluoroacetate salt

Irreversible MALT1 inhibitor

Sign-up for new product e-alerts
divider line

ASCB 2016

Win a $1,000 travel grant

ASCB travel Grant

Bio-Techne is offering 10 travel grants of $1,000 for ASCB 2016.